Heterogeneity of influenza B virus strains in one epidemic season differentiated by monoclonal antibodies and nucleotide sequences.
نویسندگان
چکیده
Seventy-three B/Victoria group strains isolated in the 1996-1997 influenza season were divided into three groups according to the degree of reactivity to monoclonal antibody 8E6. Analysis of nucleotide sequences of the HA1 region clarified that single amino acid substitutions were responsible for the difference in reactivity to 8E6.
منابع مشابه
Emergence of an influenza B virus with antigenic change.
Influenza B virus Yamagata group strains, isolated in the 2000 to 2001 influenza epidemic season, reacted poorly to the polyclonal ferret sera prepared against strains isolated earlier. The results of genetic analysis clarified that a point mutation of the nucleotide at position 126 in the HA1 region and the corresponding one-amino-acid substitution altered viral antigenicity.
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عنوان ژورنال:
- Journal of clinical microbiology
دوره 38 9 شماره
صفحات -
تاریخ انتشار 2000